Southeast Iowa Vacation Packages 2026

Photo by Erik Rowley

Your Southeast Iowa Vacation

Enjoy the flexibility to travel wherever your wanderlust takes you when you book a Southeast Iowa vacation package. From its rich history to a whole lot more, you can experience it all at your own speed. A carefully planned itinerary is a must for your trip to Southeast Iowa. Burlington, Mount Pleasant and Keokuk are a few of the most well-known cities here. Whether you're traveling for a few days or a few weeks, Expedia are here to help you organize your next dream Southeast Iowa vacation.

Stay near popular Southeast Iowa attractions

Historic Nauvoo

9.6/10 (269 reviews)

Find out about the history of Nauvoo when you spend time at Historic Nauvoo. While you're in the area, stroll along the riverfront.

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Snake Alley

8.6/10 (172 reviews)

Learn about the local history of Burlington when you take a trip to Snake Alley. Visit the area's casinos, or simply enjoy its bars.

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Lacey-Keosauqua State Park

8.6/10 (15 reviews)

Commune with nature and explore the great outdoors at Lacey-Keosauqua State Park during your travels in Keosauqua. Wander the parks and lakeside while you're in the area.

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Iowa State Penitentiary

7.2/10 (40 reviews)

After visiting Iowa State Penitentiary, make a plan to see the other sights and activities in Fort Madison. Wander the riverfront in this family-friendly area.

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Fort Madison Marina

7.6/10 (12 reviews)

Explore the waterfront in Fort Madison with a trip to Fort Madison Marina. Wander the riverfront in this family-friendly area.

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Baxter's Vineyards

7.4/10 (23 reviews)

You can enjoy a tasting or tour at Baxter's Vineyards during your travels to Nauvoo. While you're in the area, stroll along the riverfront.

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Lake Sugema

7.0/10 (2 reviews)

Commune with nature and explore the great outdoors at Lake Sugema during your travels in Keosauqua. Wander the parks and lakeside while you're in the area.

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North Lee County Historical Society

7.6/10 (17 reviews)

You can browse the exhibits at North Lee County Historical Society, a museum with a storied past, during your travels to Fort Madison. While you're in the area, stroll along the riverfront.

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Southeast Iowa Hotel Deals

Fun City Resort Hotel

3001 Winegard Drive Burlington IA

Fully refundableReserve now, pay when you stay

$127 nightly

$142 total

Sep 8 - Sep 9

Total with taxes and fees

The Inn at Old Nauvoo

1875 Mulholland St Nauvoo IL

$150 nightly

$169 total

Sep 7 - Sep 8

Total with taxes and fees

8.8/10 Excellent! (439 reviews)

"Clean room, wonderful and friendly staff ever willing to help. Property is very near all the attractions. I'll certainly go back to this place and highly recommend it to others."

Reviewed on Sep 6, 2026

AmericInn by Wyndham West Burlington

628 S Gear Ave West Burlington IA

Fully refundableReserve now, pay when you stay

$66 nightly

$74 total

Sep 20 - Sep 21

Total with taxes and fees

7/10 Good! (918 reviews)

"Well maintained."

Reviewed on Sep 3, 2026

See all 225 properties in Southeast Iowa

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.